Types of Thrombotic Thrombocytopenic Purpura The enzyme breaks up a large protein called von Willebrand factor that clumps together with platelets to form blood clots. The ADAMTS13 gene controls the enzyme, which is involved in blood clotting. Anemia is a condition in which the body has a lower than normal number of red blood cells.Ī lack of activity in the ADAMTS13 enzyme (a type of protein in the blood) causes TTP. This leads to hemolytic anemia (HEE-moh-lit-ick uh-NEE-me-uh)-a rare form of anemia. TTP also can cause red blood cells to break apart faster than the body can replace them.
PINPOINT BLEEDING SKIN
Bleeding under the skin causes the purple, brown, and red color of the purpura and petechiae.
The photograph shows purpura (bruises) and petechiae (red and purple dots) on the skin. These pinpoint-sized dots are called petechiae (peh-TEE-kee-ay). "Purpura" (PURR-purr-ah) refers to purple bruises caused by bleeding under the skin.īleeding under the skin also can cause tiny red or purple dots on the skin. "Thrombocytopenic" (throm-bo-cy-toe-PEE-nick) means the blood has a lower than normal number of platelets. "Thrombotic" (throm-BOT-ik) refers to the blood clots that form. When cut or injured, they also may bleed longer than normal. People who have TTP may bleed inside their bodies, underneath the skin, or from the surface of the skin. With fewer platelets available in the blood, bleeding problems can occur. These cell fragments stick together to seal small cuts and breaks on blood vessel walls and stop bleeding. Platelets are blood cell fragments that help form blood clots. The increased clotting that occurs in TTP also uses up platelets (PLATE-lets) in the blood. As a result, serious health problems can develop. The clots can limit or block the flow of oxygen-rich blood to the body's organs, such as the brain, kidneys, and heart. In TTP, blood clots form in small blood vessels throughout the body. Thrombotic thrombocytopenic purpura (TTP) is a rare blood disorder.
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